Macroglossia is a feature often observed in which prenatal syndrome besides Beckwith-Wiedemann?

Macroglossia is a feature often observed in which prenatal syndrome besides Beckwith-Wiedemann?

• A. Down syndrome
• B. Turner syndrome
• C. Klinefelter syndrome
• D. Noonan syndrome

Answer: (A)

Macroglossia is an enlarged tongue. While Beckwith-Wiedemann syndrome is the classic prenatal condition associated with macroglossia, this finding can also appear in Down syndrome. In Down syndrome, the tongue often appears large relative to the oral cavity, and infant hypotonia with facial structure differences can make the tongue seem more prominent, contributing to feeding difficulties and potential airway issues. The other syndromes listed do not characteristically feature macroglossia as a defining trait, so macroglossia is most commonly noted in Down syndrome besides Beckwith-Wiedemann.

Macroglossia is an enlarged tongue. While Beckwith-Wiedemann syndrome is the classic prenatal condition associated with macroglossia, this finding can also appear in Down syndrome. In Down syndrome, the tongue often appears large relative to the oral cavity, and infant hypotonia with facial structure differences can make the tongue seem more prominent, contributing to feeding difficulties and potential airway issues. The other syndromes listed do not characteristically feature macroglossia as a defining trait, so macroglossia is most commonly noted in Down syndrome besides Beckwith-Wiedemann.