Secretion of thyroid-stimulating hormone is controlled by which gland?

Secretion of thyroid-stimulating hormone is controlled by which gland?

• A. Pituitary
• B. Hypothalamus
• C. Thyroid
• D. Adrenal

Answer: (A)

The main idea is how the hypothalamic–pituitary–thyroid axis regulates thyroid-stimulating hormone. TSH is produced by the anterior pituitary, but its secretion is driven by thyrotropin-releasing hormone from the hypothalamus. The hypothalamus monitors thyroid hormone levels and other signals and releases TRH, which stimulates the pituitary to secrete TSH. TSH then stimulates the thyroid to produce T4 and T3, with the resulting thyroid hormones providing negative feedback to both the hypothalamus and pituitary to modulate further release. So, while the pituitary makes TSH, the gland that controls its secretion is the hypothalamus.

The main idea is how the hypothalamic–pituitary–thyroid axis regulates thyroid-stimulating hormone. TSH is produced by the anterior pituitary, but its secretion is driven by thyrotropin-releasing hormone from the hypothalamus. The hypothalamus monitors thyroid hormone levels and other signals and releases TRH, which stimulates the pituitary to secrete TSH. TSH then stimulates the thyroid to produce T4 and T3, with the resulting thyroid hormones providing negative feedback to both the hypothalamus and pituitary to modulate further release. So, while the pituitary makes TSH, the gland that controls its secretion is the hypothalamus.