What is the most common carcinoma of the endometrium?

What is the most common carcinoma of the endometrium?

• A. Adenocarcinoma
• B. Squamous cell carcinoma
• C. Clear cell carcinoma
• D. Serous carcinoma

Answer: (A)

The most common endometrial cancer is adenocarcinoma, specifically the endometrioid type. This tumor arises from the glandular lining of the uterus and forms malignant glands that resemble normal endometrium. It accounts for the majority of endometrial cancers and is strongly associated with unopposed estrogen exposure—think factors like obesity, nulliparity, and early menarche. While other histologies such as squamous cell carcinoma are rare for the endometrium, and clear cell or serous carcinomas do occur, they are much less common than endometrioid adenocarcinoma.

The most common endometrial cancer is adenocarcinoma, specifically the endometrioid type. This tumor arises from the glandular lining of the uterus and forms malignant glands that resemble normal endometrium. It accounts for the majority of endometrial cancers and is strongly associated with unopposed estrogen exposure—think factors like obesity, nulliparity, and early menarche. While other histologies such as squamous cell carcinoma are rare for the endometrium, and clear cell or serous carcinomas do occur, they are much less common than endometrioid adenocarcinoma.