Which tumor is hormonally active and tends to cause estrogen-related symptoms due to hormone production?

Which tumor is hormonally active and tends to cause estrogen-related symptoms due to hormone production?

• A. Granulosa cell tumor
• B. Thecoma
• C. Serous cystadenoma
• D. Dysgerminoma

Answer: (A)

Estrogen-producing tumors in the ovary are hormonally active and cause estrogen-related symptoms. The granulosa cell tumor is derived from granulosa cells that normally synthesize estrogen, so these tumors retain that capability and often secrete estrogen in excess. That excess estrogen drives endometrial proliferation and can lead to abnormal uterine bleeding in adults or precocious puberty in children. While thecoma can also produce estrogen, granulosa cell tumors are the classic, most common estrogen-secreting ovarian neoplasm, making them the best answer. The other tumors listed are not typically estrogen-secreting and thus do not commonly cause these hormonal symptoms.

Estrogen-producing tumors in the ovary are hormonally active and cause estrogen-related symptoms. The granulosa cell tumor is derived from granulosa cells that normally synthesize estrogen, so these tumors retain that capability and often secrete estrogen in excess. That excess estrogen drives endometrial proliferation and can lead to abnormal uterine bleeding in adults or precocious puberty in children. While thecoma can also produce estrogen, granulosa cell tumors are the classic, most common estrogen-secreting ovarian neoplasm, making them the best answer. The other tumors listed are not typically estrogen-secreting and thus do not commonly cause these hormonal symptoms.